Numbers are a half-assed rating system, 1 being the high end, as in "first choice to recommend". No number means I didn't want to figure out my preferences any more.

Daily

3 Sluggy Freelance -- classic webcomic. Genre: Eclectic.

1 Schlock Mercenary -- Genre: space opera with silly bits and good follow-through with consequences; it's actually quite well built.

4 Something Positive -- Genre: black humor

User Friendly -- Classic computer geek strip.

Unshelved -- librarians!

Sinfest

Weekdays, or close

2 Starslip Crisis curatorial space opera

Scary Go Round

Questionable Content -- Genre: relationships, punk? Plus little intelligent robots and a superheroine cameo.

Shortpacked -- toy store, comics

Escape from Terra. Libertarian belt miners vs. the United World.

3 Red String -- shoujo, arranged marriage problems

MWF

1 Girl Genius -- Genre: "gaslamp fantasy", or steampunk. Mad Science works, and Rules The World... badly. I love it.

1 Buck Godot (T/Th/Sat -- complements GG!)

What's New With Phil and Dixie (Sun -- complements the first two)

1 Errant Story -- Genre: High fantasy. Elves, magic, urbanism.

2 Gunnerkrigg Court

XKCD

1 Penny and Aggie -- Genre: high school relationships, sarcasm

Menage a 3 (T/R/Sat) -- sexy roommate comedy

1 Freefall -- hard SF with silly bits. Recommended.

Sore Thumbs -- a conservative Christian runs a video game store

2 Flipside -- fantasy

4 Mindmistress

Lower or Random freq

1 Order of the Stick -- DandD stick figures, with good characters and plot

1 Keychain of Creation -- Exalted (M/F)

2 Phoenix Requiem (M/R)

2 Strange Candy (R), sort of an anime Sluggy Freelance, lots of references/homages in a world-jumping plot

Jesus and Mo (T/R)

Dungeons and Denizens (T/R)

2 The Midlands -- human-mutant elves in skyscrapers, with plant-goblins and AI and lesbians and inter-dimensional shamans... a rich potpourri of coolness. Now rebooted into Heliothaumic (T/Sat, sort of)

1 Finder -- "aboriginal SF"

Nahast

4 PhD -- grad student humor

1 The Pain -- (Wed?) weekly political/weird.

Dresden Codak -- random, transhumanist

SPQR Blues -- Romans

Socks. By author of Minus, about a ghost.

Afterstrife

Goblins

Erfworld -- computer game parody

3 No Rest For the Wicked -- faerie tales

2 Cheshire Crossing -- same author as above, being released on a per-issue basis, every some months.